The two types of medicines used most often are antidepressants and benzodiazepines. Some people use both.

• Antidepressants. These include:
  • Selective serotonin reuptake inhibitors (SSRIs), such as citalopram, paroxetine, or sertraline. These are the most common medicines for panic disorder.
  • Tricyclic antidepressants (TCAs), such as clomipramine or imipramine.
  • Monoamine oxidase inhibitors (MAOIs), such as phenelzine or tranylcypromine.
  • Antidepressants with mixed neurotransmitter effects, such as venlafaxine.
• Benzodiazepines, such as alprazolam or clonazepam. They are sometimes used for panic disorder. They may be used alone or with an antidepressant.
  • These drugs can help you feel better right away. They may also be used as a part of long-term treatment, either alone or with an antidepressant.
  • They may be especially helpful if you have agoraphobia.
  • They can be taken as needed. But they can cause addiction (dependence). Symptoms often come back when you stop taking them.