How Seasonal Depression Affects Bipolar Disorder

Experiencing mood shifts based on seasonal sunlight? Exercise, stress reduction, and vitamin D may help.

Signs of seasonal bipolar disorder include feeling hopeless, tense, or stressed.

Key Takeaways

Your bipolar disorder can have a seasonal pattern to it, with depressive episodes becoming more frequent in fall and winter.

Light therapy must be used carefully as it can trigger manic reactions in people with bipolar disorder.

Getting exercise and reducing stress are good ways tocombat seasonal bipolar disorder.

Some people with bipolar disorder can track their moods by looking at the calendar: If winter is coming, they can expect to have seasonal depression. If it’s spring, they might experience mania or hypomania.

“This seasonal component is related to the amount of sunlight,” says Melvin McInnis, MD, director of psychiatry programs at the University of Michigan Depression Center in Ann Arbor. “In the wintertime, people are more depressed. The patient says, ‘Every January, I start to go down.’ Then in the spring, the amount of sunlight destabilizes their mood to the point of them becoming manic and hypomanic. We [doctors] often refer to the ‘manic month of May.’”

Seasonal Affective Disorder Versus Seasonal Bipolar Disorder

Doctors have long distinguished between seasonal depression and seasonalbipolar disorder. Seasonal depression — commonly referred to as SAD, for seasonal affective disorder — is a mood disorder brought on by the biologicaleffects of a lack of sunlight. Typically experienced in the late fall and winter, it is particularly prevalent in northern regions, according to the American Psychological Association (APA). What distinguishes seasonal bipolar disorder from SAD is the presence of a manic episode within a given period of time.

People must have a history of manic or hypomanic episodes (the extreme highs) to be diagnosed with a bipolar mood disorder, explains Ken Duckworth, MD, medical director for the National Alliance on Mental Illness (NAMI) and an assistant professor at the Harvard University Medical School. If that’s not part of their medical history, he says, then their seasonal winter response is a depressive disorder and not bipolar.

RELATED: What Psychologists Want You to Know About the Holiday Blues

Warning signs of seasonal affective disorder and an upcoming bout of depression can include feeling hopeless, tense, or stressed, and losing interest in people or activities you normally enjoy, according to Harvard University. You may notice this happens to you every year in late fall and early winter and doesn’t get better until late into the spring, Dr. Duckworth says.

Seasonal Shifts in Mood: Who Is Affected?

Why do some people experience a seasonal component to their bipolar disorder and others don’t? One of the most prominent developing theories has to do with circadian rhythms — the “biological clock” — the body’s internal, rhythmic response to changes in a 24-hour day, especially sunlight. This response is controlled by a complex set of genes commonly referred to as “clock genes.” If some of these genes are abnormal, you may have a higher risk of developing seasonal bipolar disorder, according to a study published in August 2015 in Frontiers in Psychology.

But while it’s likely that in some people there’s a bipolar-SAD connection, it hasn’t yet been proven. Duckworth says, “There’s nothing definitive.”

Gabe Howard, 38, of Columbus, Ohio, was diagnosed with bipolar disorder in 2003 and he also experiences SAD when it’s dark, cold, and snowy outside. “I definitely feel more sad in the winter,” he says. “I’m sleepier, and I’m more tired, and I can be more irritable.”

Howard has to work a little harder to stay on an even keel during the winter months. When he was first diagnosed with bipolar disorder and SAD, his doctor needed to adjust his medications for the seasons, but he hasn’t had to do that for years. Howard believes adding therapy skills — including radical acceptance, where you learn to accept what is and not turn things into catastrophes — to his treatment regimen helps him cope better with both illnesses. Also, during the winter he’s especially mindful of eating healthy and participating in activities he enjoys, such as watching hockey on TV. He also tries to sleep more, but not too much. “I find I need [to bank] more reserves in the winter,” he says.

7 Treatments for Bipolar Disorder and Seasonal Depression

If you and your doctor determine that your bipolar disorder has a seasonal component, the doctor may suggest various treatment options, particularly related to depressive episodes, which tend to be more severe among those with seasonal bipolar disorder.

1. Exercise. If the depression is mild, you may not need additional medication. Rather, you may be able to manage your depression with healthy lifestyle habits, including exercise. Take a brisk walk during the sunniest part of the day, the APAsuggests. Even short bouts of exercise can help lift your mood.

2. Maintain a routine. Keep your daily living patterns — waking, sleeping, eating — the same as much as possible, Duckworth says. “You can create a rhythm where your body will be well regulated.”

3. Light therapy. Light therapy, such as special light boxes used 30 minutes a day, can be helpful. Light therapy may work faster than medications in some people, according to NAMI. But light therapy must be used carefully. Light therapy has the potential of inducing a manic reaction in the person with bipolar disorder, Duckworth says. Too much bright light “tends to correlate with mania just as too little correlates with depression,” he explains.

RELATED: 5 Foods to Avoid If You Have Bipolar Disorder

Bright-light therapy should be seen as a regular antidepressant treatment in people who have seasonal bipolar depressive episodes, according to a study published in October 2015 in the journal L’Encephale. But it’s not a guaranteed treatment. Howard, for instance, found it didn’t work for him.

4. Melatonin. If the depression is severe, light therapy may be prescribed in combination with medications, such as melatonin. A naturally occurring chemical transmitter that helps regulate circadian rhythms, melatonin has long been used in synthetic form to reset the biological clock for people suffering from jet lag orinsomnia. But over-the-counter melatonin may not be enough. A study published in 2012 in the journal Expert Opinion on Investigational Drugs suggests thatantidepressants that regulate melatonin may be the best treatment for depressive disorders, including SAD and bipolar.

5. Stress reduction. Stress is a major contributing factor in SAD and can trigger bipolar episodes, NAMI says. It’s hard to avoid all sources of stress, but try to limit those you can. If you have seasonal bipolar disorder, don’t change jobs or your home in the dead of winter, Duckworth advises. Meditation and mindfulness also can help you manage stress, according to the APA.

6. Vitamin D. Low levels of vitamin D have been linked to depressive disorders. Researchers in Australia reported in 2014 in the journal Nutrients that for some people with a vitamin D deficiency, supplementation can work as well as antidepressants in managing depression. Howard takes vitamins, including D, year-round and finds this helps stabilize his moods. Ask your doctor to test your vitamin D levels and whether you should take supplements.

7. Plan ahead. Be proactive about your bipolar and SAD disorders, Duckworth says. Learn about your seasonal patterns of depression and know what can trigger them so that you can try to avoid them, especially in winter. Having a plan to deal with potential stressors can help, too. Know what you’ll do if a snowstorm leaves you homebound, for example. Knowing you have solutions will make it easier to deal with problems should they arise, states the bipolar caregivers guide of the University of Melbourne.

The good news about seasonal bipolar disorder relates to the management of your symptoms. Unlike people with bipolar disorder without a seasonal component, you can anticipate the coming of your mood shift simply by watching the calendar. You and your care team can be prepared with a solid treatment plan in hand.

Additional reporting by Beth W. Orenstein.

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9 Natural Therapies for Bipolar Depression

When combined with prescribed medication, these alternative approaches may help you better manage the symptoms of bipolar disorder.

Key Takeaways

Talk to your doctor about any complementary or integrative health therapy you want to try to make sure you’re doing so safely.

Managing bipolar disorder may require multiple strategies, including medication and complementary therapies.

Consider adding approaches with some science behind them, like St. John’s wort, SAMe, or fish oil supplements, or traditional Chinese medicine.

Bipolar disorder requires managing two distinct categories of symptoms. Manic symptoms may include impulsive behavior, excessive irritability, and anxiety, while depressive symptoms may include a low mood, poor appetite, and emotional indifference, according to the National Institute of Mental Health. Though there aren’t many complementary or alternative medicine (CAM) remedies for manic behavior, a few non-prescription therapies may help alleviate depression. Most people who have bipolar disorder spend the majority of their time depressed rather than manic, notes the National Institutes of Health.

 

But just because CAM therapies exist doesn’t mean that people with bipolar disorder should throw away their antidepressants. “Bipolar is a very serious, lifelong disorder,” says Philip Muskin, MD, professor of psychiatry at Columbia University Medical Center in New York City. “If you need an antidepressant, you should take it. These other types of therapies are additional or complementary rather than alternative.” 

The complementary and non-pharmacological treatments that have shown some benefit for the depressive side of bipolar disorder are:

1. Rhodiola

Officially known as rhodiola rosea, this herb has been used for years to help manage stress and has also demonstrated positive effects on people struggling with depression. While rhodiola doesn’t ease depression to the extent that an antidepressant will, it has fewer side effects, according to a study published in 2015 in Phytomedicine. “Rhodiola is mildly stimulating,” Dr. Muskin notes. “I wouldn’t use it as a solo therapy, but it is a good adjunct for someone who is on antidepressantsand feels like they [still] don’t have a lot of energy.”

2. SAMe

SAMe, or S-adenosylmethionine, is a coenzyme found naturally in the body that has been extensively researched and shown to reduce symptoms in people with major depressive disorder, according to a review of research published in 2015 in CNS & Neurological Disorders – Drug Targets. But SAMe should be used with caution in people with bipolar disorder who are suffering from depression because it can actually provoke mania, according to the National Center for Complementary and Integrative Health (NCCIH). It should be used only under the direct supervision of a physician.

RELATED: Are You Depressed, Bipolar, or Just Human?

“Anything that is a real antidepressant can cause mania in bipolar people,” Muskin says, “so there is some risk that a patient taking SAMe might become manic.” Several clinical trials are now underway to determine the best way to use SAMe in people with depression-related disorders as well as bipolar disorder.

3. St. John’s Wort

This herb, which is often used in Europe for mood management, is one of the better-known natural mood enhancers. Even so, evidence is mixed on whether St. John’s wort actually has a positive effect on major depression or bipolar disorder. The NCCIH states that St. John’s wort may help with depression but can also cause psychosis, and the agency warns that it could interact with many other medications people with bipolar disorder may be taking. St John’s wort has been shown to have similar side effects to some antidepressant medications because it appears to affect the body in a similar way, according to 2015 research published in the journal Clinical and Experimental Pharmacology and Physiology.

4. Meditation

People who meditate using a supervised mindfulness-based cognitive therapy approach may see a reduction in depression that directly correlates to how many days they meditate. The more they meditated, the fewer symptoms they had, according to a study published in 2013 in Behaviour Research and Therapy.

5. Omega-3 Fatty Acids

People with bipolar disorder may have extra motivation to start eating more fish that are heavy in omega-3s, such as salmon, mackerel, and sardines, or they may want to consider taking omega-3 supplements. That’s because the anti-inflammatory effects of omega-3 fatty acids could help regulate mood, according to research published in 2015 in the Journal of the American College of Nutrition. Adding about 300 milligrams of omega-3s each day to a depression treatment plan can enhance results, according to research published in 2012 in the journal Polish Psychiatry. “If you look at countries where they eat a lot of fish, they have a relatively low incidence of bipolar disorder,” Muskin says. “In the brain, we think omega-3s might help with moving neurotransmitters in and out, which may help stabilize moods.”

6. Light Therapy

People with bipolar disorder may have interrupted circadian rhythms, which means their daily biological clock isn’t working well. A number of strategies may help to reset this internal clock and improve bipolar management, according to a 2012 research review published in Dialogues in Clinical Neuroscience. These include timed exposure to periods of light and darkness and a forced change in sleep times. Be sure to discuss these or other similar strategies with your doctor before you try them on your own.

7. Traditional Chinese Medicine

This approach relies on certain herbal combinations and comprehensive changes in diet and daily habits. There is not enough evidence yet to support or rule out Chinese herbal preparations, concludes a review published in 2013 in Evidence-Based Complementary and Alternative Medicine. But some combinations may benefit mood disorders. Work with a practitioner trained in the field in collaboration with your doctors.

8. Interpersonal and Social Rhythm Therapy

This technique teaches people with bipolar disorder to maintain a more regular schedule in all aspects of life, including sleeping, waking, eating, and exercise. It has been shown to improve daily functioning, according to a study published in 2015 in Bipolar Disorders.

9. Eye Movement Desensitization and Reprocessing Therapy

EMDR uses a supervised program of eye movements, combined with actively remembering traumatic experiences, to improve symptoms. This approach can be helpful to people who have bipolar disorder and a history of trauma, according to research published in 2014 in the journal Psychiatry Research. 

Complementary Bipolar Treatments: A Few Words of Caution

“The reality is that there is not a lot of data on complementary therapies for bipolar disorder,” Muskin says. “That doesn’t mean these products shouldn’t be used, but when patients try to find out about them, they shouldn’t expect to be able to go to [websites] like The New England Journal of Medicine and download a lot of articles.”

Muskin recommends ConsumerLab as a reputable site where people can go to research complementary therapies. “You can find out whether or not the product you’re buying really contains the product you think it does, as well as what it’s indicated for and whether it has contaminants,” he says. The National Institutes of Health Office of Dietary Supplements also provides an extensive online database of dietary supplements that includes detailed product and manufacturer information.

Most of these therapies are safe, and there is limited evidence of negative interactions with prescription medications. Regardless, patients and their family members should actively research these products and discuss options with a psychiatrist before taking them, especially because complementary therapies do not undergo the same strict review process as pharmaceutical medications.

Additional Reporting by Madeline Vann, MPH.

Last Updated: 1/15/2016

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Lithium Beats Newer Meds for Bipolar Disorder

Lower rates of self-harm, accidental injury seen.

People taking one of the alternative mood stabilizers were 40 percent more likely to harm themselves compared to patients on lithium.
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Thursday, May 12, 2016

Lithium outperforms newer mood stabilizers in the treatment of bipolar disorder, a new study has found.

Patients taking lithium had lower rates of self-harm and unintentional injury compared to those taking other bipolar drugs, such as valproate (Depacon, Depakote), olanzapine (Zyprexa) or quetiapine (Seroquel), said lead researcher Joseph Hayes. He is a fellow of psychiatry at University College London.

“This is important because people with bipolar disorder are 15 times more likely to die by suicide and six times more likely to die by accidental injury than the general population,” Hayes explained.

People taking one of the alternative mood stabilizers were 40 percent more likely to harm themselves compared to patients on lithium, Hayes and his colleagues found.

And people on valproate or quetiapine were 32 percent to 34 percent more likely to fall victim to unintentional injury, most likely while experiencing a manic episode, the researchers said.

“Lithium still is the gold standard for the treatment of bipolar. We really haven’t had a medication that surpasses lithium, as far as we know,” said Dr. Raphael Braga. He is physician-in-charge of the Center for Treatment and Research of Bipolar Disorder at Zucker Hillside Hospital in Glen Oaks, N.Y., and was not involved with the study.

RELATED: Why Bipolar Disorder Is Often Misdiagnosed

Hayes noted that lithium has been used for more than half a century to treat bipolar disorder, but it’s still not clear how the drug stabilizes a person’s mood.

Bipolar disorder, which used to be called manic depression, is characterized by extreme mood swings ranging from emotional highs to depressive lows.

The researchers undertook their study following evidence reviews and studies that suggested lithium might be better than newer medications at preventing suicide and self-harm.

These studies have contended that lithium achieves these results by reducing symptoms such as depression, aggression, risk-taking and impulsive behavior, according to background notes in the study.

Lithium can be hard on the body, the study authors said, increasing a person’s risk of kidney and thyroid disease, but even that may have a positive side in bipolar patients. Because patients must be closely monitored for side effects, they are in more frequent contact with doctors who can pick up on emotional problems that lead to suicide, the researchers contend.

To compare lithium against newer medications, Hayes and his colleagues collected medical data on nearly 6,700 people diagnosed as bipolar and prescribed only one of the drugs — lithium, valproate, olanzapine or quetiapine.

The investigators found that people on lithium were less likely to harm themselves, either intentionally or by accident.

The suicide rate was lower in the lithium group, but too few suicides occurred to allow accurate risk estimates, the study authors said.

The findings were published online May 11 in the journal JAMA Psychiatry.

Lithium can cause kidney disease and hypothyroidism (underactive thyroid gland), Braga and Hayes said.

Doctors need to carefully weigh benefits versus harm when prescribing lithium to people with kidney or thyroid problems, and “if these are severe, it should be avoided,” Hayes said. “Lithium [also] needs to be reviewed on an individual patient basis before pregnancy.”

Braga said psychiatrists often require patients taking lithium to undergo lab tests every three to six months, to make sure their kidney function hasn’t been compromised.

Even with this, lithium is much cheaper than the other medications in the study, Braga said. Hayes noted a 2008 study that found lithium was nearly $500 cheaper per month compared with olanzapine.

“Lithium is a great drug,” Braga said. “It’s definitely a drug every clinician should think about when prescribing for bipolar disorder.”

Last Updated: 5/12/2016

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Bipolar Disorder Awareness Day

In 1990, Congress designated the first full week of every October to be National Mental HealthAwareness Week. This year that week is October 7-13, 2007 and October 11th is both National Depression Screening Day, sponsored by Screening for Mental Health, Inc., and Bipolar Disorder Awareness Day. Bipolar Disorder Awareness Day is organized by the National Alliance on Mental Illness (NAMI), a non-profit group which is the nation’s largest grassroots mental health organization dedicated to improving the lives of persons living with serious mental illness and their families.

Bipolar disorder is also called manic depression or manic-depressive illness, but its treatment is different from that of depression (see below). It is a chronic brain disorder that causes extreme shifts in mood, energy and ability to function. It is characterized by episodes of mania (being overly ‘high’) and depression (being irritable, sad or hopeless) that can last from days to months. Symptoms often begin in adolescence or early adulthood and can result in poor school performance, poor job performance, damaged relationships, substance abuse, criminal or other irrational behavior and even suicide. Oftentimes depression dominates the clinical picture and mania may go unrecognized, especially if it is mild (called hypomania) or occurs only rarely. However, the recognition of mania is critical to the proper diagnosis of bipolar disorder, which might otherwise be diagnosed as depression (also called unipolar depression).

The treatment of bipolar disorder is different from the treatment of depression. Everyone knows that depression is treated with anti-depressants. But bipolar disorder, even though it has depression as a component, needs to be treated with mood stabilizers first and foremost. Anti-depressants play a much lesser role, if any, in the treatment of bipolar disorder, and they can actually make the illness worse (especially if used alone without mood stabilizers). You can see why proper diagnosis is so important.

In recognition of Bipolar Awareness Day, HealthTalk has created a Special Feature page with a wide variety of useful information, including treatment information, on this illness.

Bipolar Awareness Day was created by NAMI and Abbott Laboratories to, according to the NAMI Web site “increase awareness of bipolar disorder, promote early detection and accurate diagnosis, reduce stigma, and minimize the devastating impact on the 2.3 million Americans presently affected by the disorder.” The government’s National Institute of Mental Health states that about 5.7 million American adults have bipolar disorder in any given year. Other estimates put the number of people with bipolar disorder at 10 million.

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Mood Stabilizers for Bipolar Disorder

Mood stabilizers are medications that can treat the extreme highs of bipolar disorder. Find out about the risks and benefits of these drugs.

Key Takeaways

Mood stabilizers are used along with antidepressants to balance out the extreme highs of bipolar disorder.

Medications for bipolar disorder must be taken long term, yet they carry risks for potentially serious side effects.

Bipolar disorder is often treated with medications referred to as mood stabilizers, such aslithium or Depakote (valproate) and Tegretol(carbamazepine).

These medications can be very effective in treating hypomania or mania and preventing the recurrence of bipolar episodes.

Types of Mood Stabilizers for Bipolar Treatment

Bipolar disorder is different in different people, and a treatment that can help someone else may not work for you, and vice versa.

But in general, mood stabilizers should always be used along with antidepressantsto treat bipolar disorder in order to reduce the risk for mania, according to a 2014 study published in the American Journal of Psychiatry.

Mood-stabilizing medications that your doctor may recommend include:

Lithium. This drug can help balance out the emotional highs and lows of bipolar disorder.

“Lithium has this curious property of working both against mania and depression,” says Gary Sachs, MD, founding director of the Bipolar Clinic and Research Program at Massachusetts General Hospital in Boston and associate clinical professor of psychiatry at Harvard Medical School.

Lithium appears to work by helping to normalize brain activity. It also helps prevent both depression and mania relapses.

Valproate and carbamazepine. Valproate (also called valproic acid) and carbamazepine were first used to treat convulsions in people with epilepsy.

Researchers then found that these drugs could also help treat bipolar disorder symptoms. “Valproic acid and carbamazepine have, in fact, been shown to be efficacious for the treatment of acute mania,” says Dr. Sachs.

The two drugs work by calming the brain, resulting in a better and more stable mood.

RELATED: 7 Ways to Get the Best Bipolar Care

These medications can help with bipolar episodes, especially the rapid-cycling variety in which moods change from mania to depression and back again over a period of hours or days.

Sachs says there is also evidence supporting the use of valproate to help prevent recurrences of bipolar episodes.

However, there’s limited evidence that valproate on its own is very effective as a long-term treatment, according to a 2013 research review by the Cochrane Database of Systematic Reviews.

Combination of medications. Lithium, valproate, and carbamazepine are often used together or in combination with dopamine-blocking medications for a more potent mood-stabilizing effect in bipolar treatment.

Special Considerations With Bipolar Treatment

Lithium is usually preferred for the treatment of bipolar disorder in children and adolescents because the safety of valproate and carbamazepine is still being evaluated in these groups.

For instance, numerous studies indicate that valproate puts girls and women at risk of hormonal abnormalities and polycystic ovary syndrome when the medication is taken before age 20.

In addition, if you are a woman with bipolar disorder you will need to talk with your physician about which medications are least risky to take when trying to conceive, during pregnancy, in the postpartum period, and while nursing.

All medicinal bipolar disorder treatments could harm a developing fetus or a breastfeeding baby, but your doctor may be able to tell you about new bipolar treatments that are thought to be safer during pregnancy and lactation.

Side Effects of Mood Stabilizers

Depending on the medication you are using, your doctor or pharmacist can tell you about side effects you could experience.

In general, lithium is commonly associated with:

  • Drowsiness
  • Weakness
  • Nausea
  • Fatigue
  • Tremor
  • Thirst
  • Frequent urination
  • Weight gain
  • Thyroid problems

Side effects of valproate and carbamazepine commonly include:

  • Gastrointestinal problems
  • Headache
  • Double vision
  • Dizziness
  • Anxiety
  • Confusion
  • Liver problems

Any doctor can prescribe these medications, but it’s a good idea to see apsychiatrist, who’s trained to deal with mental illnesses such as bipolar disorder.

You will probably take these medications over the long term, and you may need to add medications if you have manic or depressive episodes that break through despite the treatment.

People with bipolar disorder usually need more than one medication. Over time, working with your psychiatrist, you can determine which bipolar treatment regimen works best for you.

Follow-Up Care Is Key With Bipolar Disorder

Although there are effective treatments for bipolar disorder, there is no cure. Because it’s a long-term illness, ongoing treatment is needed to control your symptoms.

Even if you are taking your medication as directed by your doctor, you may experience mood changes or lingering symptoms. If you have another mental illness, your treatment for bipolar disorder may also be more complicated.

Working closely and openly with your doctor is key to finding the treatment plan that is most effective for you.

Article updated by Mary Elizabeth Dallas and medically reviewed by Lindsey Marcellin, MD, MPH

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