Types of Bipolar Disorder

There are several types of bipolar disorder; all involve episodes of depression and mania to a degree.

Bipolar disorder is a lifelong illness. Episodes of mania and depression eventually can occur again if you don’t get treatment. Many people sometimes continue to have symptoms, even after getting treatment for their bipolar disorder. Here are the types of bipolar disorder:

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Bipolar Disorder Overview

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  • Bipolar I disorder involves periods of severe mood episodes from mania to depression.
  • Bipolar II disorder is a milder form of mood elevation, involving milder episodes of hypomania that alternate with periods of severe depression.
  • Cyclothymic disorder describes brief periods of hypomaniac symptoms alternating with brief periods of depressive symptoms that are not as extensive or as long-lasting as seen in full hypomanic episodes or full depressive episodes.
  • “Mixed features” refers to the occurrence of simultaneous symptoms of opposite mood polarities during manic, hypomanic or depressive episodes. It’s marked by high energy, sleeplessness, and racing thoughts. At the same time, the person may feel hopeless, despairing, irritable, and suicidal.
  • Rapid-cycling is a term that describes having four or more mood episodes within a 12-month period. Episodes must last for some minimum number of days in order to be considered distinct episodes. Some people also experience changes in polarity from high to low or vice-versa within a single week, or even within a single day, meaning that the full symptom profile that defines distinct, separate episodes may not be present (for example, the person may not have a decreased need for sleep). Sometimes called “ultra-rapid” cycling, there is debate within psychiatry as to whether this phenomenon is a valid or well-established feature in bipolar disorder. A pattern of rapid cycling can occur at any time in the course of illness, although some researchers believe that it may be more common at later points in the lifetime duration of illness. Women appear more likely than men to have rapid cycling. A rapid-cycling pattern increases risk for severe depression and suicide attempts. Antidepressants may sometimes be associated with triggering or prolonging periods of rapid cycling. However, that theory is controversial and is still being studied.
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Mood Swings and Bipolar Disorder

The mood swings of bipolar disorder can be profoundly destructive. Depression can make you isolate yourself from your friends and loved ones. You may find it impossible to get out of bed, let alone keep your job. During manic periods, you may be reckless and volatile.

Picking up the pieces after a mood episode can be hard. The people you need most — especially your friends and family — may be angry with you or reluctant to help.

The best way to avoid these mood episodes is to get treatment for bipolar disorder. But unfortunately, periods of hypomania, mania, or depression aren’t completely preventable. Even people who always take their medication and are careful with their health can still have mood swings from time to time.

That’s why it’s important to catch changes in your mood, energy levels, and sleeping patterns before they develop into something serious.

Mood Swing Triggers in Bipolar Disorder

At first, mood swings may take you by surprise if you have bipolar disorder. But over time, you might start to see patterns or signs that you’re entering a period of mania or depression. Aside from a shift in your mood, look for changes in your:

  • Sleep patterns
  • Energy level
  • Alcohol or drug use
  • Sex drive
  • Self-esteem
  • Concentration

Mood episodes in bipolar disorder often occur spontaneously, for no particular reasons. Sometimes, however, you may discover particular “triggers” — situations or events that can provoke a period of mania or depression, such as sleep deprivation, changing seasons, or crossing multiple time zones when traveling. Some people find they’re more likely to become depressed or manic during stressful times at work or during holidays. Many people see seasonal patterns to their mood changes. Of course, not everyone can identify triggers. Also, some triggers can’t be anticipated or avoided, like a serious illness or a traumatic event.

One good way to see patterns or triggers in your bipolar disorder is to keep a journal. Make note of big events, stresses, your medication dosage, and the amount of sleep you’re getting. Over time, you might see some patterns emerge.

If you can recognize triggers for periods of mania or depression, you can prepare for times when you might be most vulnerable. Ask for more help from co-workers. Have your family and friends check in more often so you get extra support.

If you see the signs of potential trouble, get help. Don’t wait for the mood episode to pass on its own. With quick intervention, you might be able to stop a very minor mood swing from becoming a serious problem.

The Appeal of Mania in Bipolar Disorder

When people with bipolar disorder are depressed, they almost always know that something is wrong. Nobody likes feeling that way.

But it’s different for people who are hypomanic or manic. Often, they don’t think anything is wrong. Or if they notice a difference in their mood and personality, they think it’s an improvement.

Mania and hypomania can be seductive. You might feel more energized, creative, and interesting. You might be able to get extraordinary amounts of work done. So what’s the problem?

Manic phases often turn destructive. Some consequences of a manic episode can’t be undone. You can wipe out your savings account. You can have affairs that ruin your marriage. You can lose your job. Most dangerous of all, mania can make you do things that risk your life or the lives of others. And manias are often followed by depressive episodes. Effectively treating a mania or hypomania may help reduce the risk of developing a future depression.

Although hypomania or mania can feel good at the moment, in the long run, you’ll be happier, healthier, more productive, and more successful if you can maintain a stable mood.

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Maintenance Treatment for Bipolar Disorder

In bipolar disorder, after remission from an acute episode of mania or depression, a person is at an especially high risk of relapse for about six months. Thus, continuation and maintenance of (ongoing) therapy is often recommended as treatment for bipolar disorder.

Anyone who has experienced two or more episodes of bipolar disordergenerally is considered to have lifelong bipolar disorder, where the goal focuses not only on treating current symptoms but also preventing future episodes. That person should have maintenance therapy. Once your doctor has helped stabilize the moods of the acute phase of the disorder (either a manic or depressive episode), drug therapy is continued indefinitely — sometimes at lower doses.

It is important to remember this: Even if you have been without bipolar symptoms for several months, do not stop taking your medications. Your doctor may lower your doses, but discontinuation of medications will put you at risk for recurrence of bipolar symptoms.

Aripiprazole (Abilify), lamotrigine (Lamictal),  lithium ,  olanzapine(Zyprexa),  risperidone (Risperdal) Consta, and  quetiapine (Seroquel) or ziprasidone (Geodon), (either one in combination with lithium or valproate) are the only drugs that have been approved by the FDA specifically for maintenance therapy for bipolar disorder. These medications can differ in their ability to prevent manic versus depressive episodes, as well as in their side effects. However, many other drugs used to treat manic episodes are also used for maintenance treatment.

These drugs include:

A combination of these drugs may also be used.

Lamotrigine (Lamictal) for Bipolar Disorder

Lamictal is approved by the FDA for the maintenance treatment of adults with bipolar disorder. It has been found to help delay bouts of depression, mania, hypomania (a milder form of mania), and mixed episodes in those being treated with standard therapy. It is especially effective in the prevention of bipolar depression. It is the first FDA-approved therapy since lithium for maintenance in bipolar disorder.

Lamictal is considered a mood-stabilizing anticonvulsant and is most commonly prescribed to prevent or control seizures in the treatment of epilepsy. Recent studies have shown it may possess antidepressanteffects in bipolar disorder.

Lamictal Side Effects

Lamictal comes in several types of tablets, such as chewable or orally disintegrating. It adds to the effects of other central nervous systemsuppressants such as alcohol — and to those found in many antihistamines, cold medications, pain medications, and muscle relaxants. Check with your doctor before taking any of these.

Three out of every 1,000 people taking Lamictal will develop a rash. Sometimes the rash can prove serious or even fatal. If a rash develops, you should consult your doctor  immediately and the drug may need to be stopped promptly.

Common side effects of Lamictal include:

Medication errors have occurred in filling Lamictal prescriptions because other drugs have similar names, like  labetalol,  Lamisil, lamivudine, Lomotil, and Ludiomil. To avoid confusion, make sure the drug name is clearly written on your prescription.

Lithium for Bipolar Disorder

Lithium (brand names include Eskalith or Lithobid) is the most widely used and studied medication for treating bipolar disorder. It has been used for more than 50 years and helps reduce the severity and frequency of manic states. It may also help relieve bipolar depression.

People with bipolar disorder may take lifelong lithium as maintenance therapy to prevent relapses. When lithium treatment stops, relapses can occur within six months in 90% of patients. Moreover, subsequent lithium treatment may sometimes be less effective, particularly if lithium is stopped abruptly rather than gradually (meaning, over a period of 2 weeks or longer).

Studies show that lithium can significantly reduce the risk of suicideamong people with bipolar disorder. It also helps prevent future manic episodes.

Lithium is a simple salt that acts on a person’s central nervous system. Doctors don’t know exactly how lithium works to stabilize mood. However, it helps people with bipolar disorder have more control over their emotions and cope better with the problems of daily life.

When lithium is used as part of maintenance therapy for bipolar disorder, your doctor will want to take regular blood tests during your treatment because it can affect kidney and thyroid function. Blood tests will also help your doctor monitor the level of lithium in your blood. Your doctor also will probably suggest you drink two or three quarts of water or fluid a day during treatment and use a normal amount of salt in your food. Both salt and fluid can affect the levels of lithium in your blood, so its important to consume enough every day.

Lithium Side Effects

About 75% of people who take lithium for bipolar disorder have some side effects, although they may be minor. Sometimes side effects can be relieved by changing the dose of lithium. Never change your dose or drug schedule on your own. If you are having any problems, talk to your doctor about your options.

Common side effects of lithium include:

Particularly bothersome tremors can be treated with additional medication.

There are a few serious risks to consider. Lithium may weaken bones in children. The drug has also been linked to a specific birth defect in heartvalve formation occurring in 1 in 1000 to 1 in 2000 patients and should be administered with caution to pregnant women. Also, in a very few people, long-term lithium treatment can interfere with kidney function.

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Medications for Bipolar Disorder

Finding the right bipolar medication regimen can be challenging for you and your doctor. For most people with bipolar disorder, two or more medications are used in combination to address the varied symptoms that are often involved.  Find information here about coping with side effects and tips for sticking to your treatment plan.

Bipolar Medications

 

Lithium for Bipolar Disorder

Lithium has been used for years for bipolar disorder. Find out what to expect if you’re taking lithium.

Lithium for Bipolar Disorder

 

Bipolar Disorder and Anticonvulsants

Anticonvulsants were originally used to treat seizures. Find out how they can help bipolar disorder, too.

Bipolar Disorder and Anticonvulsants

 

Antipsychotic Drugs for Bipolar Disorder

Did you know that some people with bipolar disorder get short- and long-term help from antipsychotic medications? Learn more here.

Antipsychotics for Bipolar Disorder

 

Calcium Channel Blockers for Bipolar Mania

Here’s where to learn why doctors sometimes prescribe certain of these blood pressure drugs for bipolar mania.

Calcium Channel Blockers for Bipolar Mania

 

Benzodiazepines for Bipolar Disorder

For short-term relief of manic symptoms, benzodiazepines can be very helpful. Here’s where to learn when, and how, they are used.

Benzodiazepines for Bipolar Disorder

 

Electroconvulsive Therapy for Bipolar

Current techniques are much gentler than what you’ve seen in the movies. Discover why doctors sometimes recommend this treatment for bipolar disorder.

Electroconvulsive Therapy for Bipolar Disorder

 

Antidepressants for Bipolar Disorder

Find out how antidepressants can help bipolar disorder — and when they shouldn’t be used.

Antidepressants for Bipolar Disorder

 

Paxil, Prozac, Lexapro, and Zoloft for Bipolar Disorder

The so-called SSRI antidepressants are sometimes used to treat depression in people with bipolar disorder, although their safety and efficacy in bipolar disorder is controversial.

Paxil, Prozac, Lexapro, Zoloft for Bipolar Disorder

 

MAOI Antidepressants and Bipolar Disorder

Monoamine oxidase inhibitors (MAOIs) are unique antidepressants — including Emsam, Marplan, Nardil, and Parnate — that are often avoided yet under-utilized for depression associated with bipolar disorder. Here’s more information about how they work and their unique safety concerns.

 

MAOI Antidepressants and Bipolar Disorder

 

Effexor, Remeron, and Wellbutrin for Bipolar Disorder

The “atypical” antidepressants may have a role in treating bipolar depression. Find out more.

Effexor, Remeron, Wellbutrin for Bipolar Disorder

 

Tricyclic Antidepressants and Bipolar Depression

The older tricyclic antidepressants are only rarely recommended for patients with bipolar depression. Learn more about these drugs.

Tricyclic Antidepressants and Bipolar Depression

 

Maintenance Medications for Bipolar Disorder

Once a depressive or manic phase is under control, people with bipolar disorder often continue treatment that keeps them on an even keel. Learn more here.

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Calcium Channel Blockers for Bipolar Disorder

Calcium channel blockers are typically used to treat high blood pressure or heart problems. Some have also been studied experimentally to treat mania or depression in bipolar disorder. Thus far, there is still uncertainty about whether or not they are effective for treating bipolar disorder.

Calcium channel blockers block the small pores in cells (called L-type calcium channels) that allow calcium to move in and out, and widen blood vessels as well as affect the activity of nerve cells. It’s not clear exactly how these drugs might affect mood, but research suggests that at least in some people with bipolar disorder, the way the brain uses calcium to regulate various functions within nerve cells may not work properly. The use of calcium channel blockers to treat bipolar disorder outside of research studies is experimental.

Calcium channel blockers that have been studied to treat bipolar disorder include:

Side Effects of Calcium Channel Blockers

Calcium channel blockers can lower blood pressure, so it is important that blood pressure is monitored during treatment. Low blood pressure can cause dizziness and light-headedness.  Sometimes, a headache can develop after taking certain calcium channel blockers. These headaches should gradually disappear once you have been taking the medication for a while. Talk to your doctor if headaches continue. Some people also report tenderness, swelling, or bleeding of the gums when starting to take calcium channel blockers. Regular brushing, flossing, and gum massages along with routine dental visits can help lessen this effect. As with any medication, it is important to see your doctor regularly to make sure the drug is working properly.

Calcium channel blockers tend to cause fewer serious side effects than many of the drugs that are traditionally used to treat bipolar disorder. However, it is important to remember that they are not as well studied as traditional medicines for bipolar and their effectiveness has not been well-established.

Common calcium channel blocker side effects include:

  • Slowed heart rate or irregular heart rhythm
  • Flushing, a pounding sensation in the head, dizziness, headache
  • Leg swelling
  • Decreased blood pressure
  • Tingling sensations in the arms or legs
  • Weakness
  • Constipation

Talk to your doctor if you are pregnant or could become pregnant during treatment. It isn’t known if these drugs could harm the fetus.

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